Clinical and genetic features of human metapneumovirus infection in children
Identifieur interne : 000906 ( Main/Exploration ); précédent : 000905; suivant : 000907Clinical and genetic features of human metapneumovirus infection in children
Auteurs : Ji Young Park [Corée du Sud] ; Ki Wook Yun [Corée du Sud] ; Jae Woo Lim [États-Unis] ; Mi Kyung Lee [Corée du Sud] ; In Seok Lim [Corée du Sud] ; Eung Sang Choi [Corée du Sud]Source :
- Pediatrics International [ 1328-8067 ] ; 2016-01.
Abstract
Background: Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children. Methods: From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at <38.5°C and lasting <72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group. Results: Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, P = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, P = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, P < 0.001) and dyspnea (2.5% vs 15.5%, P = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups. Conclusion: Two distinct clinical presentations of hMPV infection were identified in this study.
Url:
DOI: 10.1111/ped.12782
Affiliations:
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genetic features of human metapneumovirus infection in children</title><author><name sortKey="Park, Ji Young" sort="Park, Ji Young" uniqKey="Park J" first="Ji Young" last="Park">Ji Young Park</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yun, Ki Wook" sort="Yun, Ki Wook" uniqKey="Yun K" first="Ki Wook" last="Yun">Ki Wook Yun</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation></affiliation></author><author><name sortKey="Lim, Jae Woo" sort="Lim, Jae Woo" uniqKey="Lim J" first="Jae Woo" last="Lim">Jae Woo Lim</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience and Behavioral Biology, Emory College of Arts and Sciences, Emory University, Georgia, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Mi Kyung" sort="Lee, Mi Kyung" uniqKey="Lee M" first="Mi Kyung" last="Lee">Mi Kyung Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, Chung‐Ang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lim, In Seok" sort="Lim, In Seok" 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INTERNATIONAL</title><idno type="ISSN">1328-8067</idno><idno type="eISSN">1442-200X</idno><imprint><biblScope unit="vol">58</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="22">22</biblScope><biblScope unit="page" to="26">26</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2016-01">2016-01</date></imprint><idno type="ISSN">1328-8067</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1328-8067</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children. Methods: From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at <38.5°C and lasting <72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group. Results: Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, P = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, P = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, P < 0.001) and dyspnea (2.5% vs 15.5%, P = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups. Conclusion: Two distinct clinical presentations of hMPV infection were identified in this study.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, Ji Young" sort="Park, Ji Young" uniqKey="Park J" first="Ji Young" last="Park">Ji Young Park</name></region><name sortKey="Choi, Eung Sang" sort="Choi, Eung Sang" uniqKey="Choi E" first="Eung Sang" last="Choi">Eung Sang Choi</name><name sortKey="Lee, Mi Kyung" sort="Lee, Mi Kyung" uniqKey="Lee M" first="Mi Kyung" last="Lee">Mi Kyung Lee</name><name sortKey="Lim, In Seok" sort="Lim, In Seok" uniqKey="Lim I" first="In Seok" last="Lim">In Seok Lim</name><name sortKey="Yun, Ki Wook" sort="Yun, Ki Wook" uniqKey="Yun K" first="Ki Wook" last="Yun">Ki Wook Yun</name></country><country name="États-Unis"><noRegion><name sortKey="Lim, Jae Woo" sort="Lim, Jae Woo" uniqKey="Lim J" first="Jae Woo" last="Lim">Jae Woo Lim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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